Mouse Prrt1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Prrt1
Locus ID	260297
Kit Components	GA215886G1, Prrt1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA215886G2, Prrt1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA215886G3, Prrt1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_030890, NM_001368728, NM_001368729, NM_001368730
Synonyms	Bat-4; Bat4; D17H6S54E; DSPD1; G5b; NG5; ORF31
Summary	Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function (PubMed:29490264). Regulates AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses (PubMed:29490264, PubMed:31216424). Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression (PubMed:31216424).[UniProtKB/Swiss-Prot Function]

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