Mouse Usp49 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Usp49
Locus ID	224836
Kit Components	GA213734G1, Usp49 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213734G2, Usp49 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213734G3, Usp49 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_198421
Synonyms	C330046L10Rik; Gm545
Summary	Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons (By similarity).[UniProtKB/Swiss-Prot Function]

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