Mouse Socs2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Socs2
Locus ID	216233
Kit Components	GA213337G1, Socs2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA213337G2, Socs2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA213337G3, Socs2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001168655, NM_001168656, NM_001168657, NM_007706
Synonyms	8030460M17; AI527257; AW108012; CIS2; Cish2; D130043N08Rik; hg; JAB; SOCS-2; SSI-2
Summary	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).[UniProtKB/Swiss-Prot Function]

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