Mouse Stxbp5l activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Stxbp5l
Locus ID	207227
Kit Components	GA212804G1, Stxbp5l gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212804G2, Stxbp5l gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212804G3, Stxbp5l gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001114611, NM_001114612, NM_001114613, NM_172440
Synonyms	9430094L02; A830015P08Rik; LLGL4; T2dm1; t2md1; tomosyn-2
Summary	Plays a role in vesicle trafficking and exocytosis inhibition (PubMed:25002582). In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane (PubMed:21998599). Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (PubMed:24744148). Promotes as well axonal outgrowth (By similarity).[UniProtKB/Swiss-Prot Function]

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