Mouse Phf21a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Phf21a
Locus ID	192285
Kit Components	GA212719G1, Phf21a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA212719G2, Phf21a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA212719G3, Phf21a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001109690, NM_001109691, NM_001346704, NM_138755, NM_001362829, NM_001362830, NM_001362831, NM_001362832, NM_001362833
Synonyms	80kDa; Bhc; Bhc80; D030065N23Rik; PFTF1
Summary	Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (By similarity).[UniProtKB/Swiss-Prot Function]

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