Mouse B4gat1 activation kit by CRISPRa

CAT#: GA212158

B4gat1 CRISPRa kit - CRISPR gene activation of mouse beta-1,4-glucuronyltransferase 1



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

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经常一起买 (1)
Rabbit Polyclonal Anti-B3gnt1 Antibody
    • 100 ul

CNY 5,250.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol B4gat1
Locus ID 108902
Kit Components

GA212158G1, B4gat1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA212158G2, B4gat1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA212158G3, B4gat1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_175383
Synonyms 1500032M01Rik; B3gnt1; B3gnt6; BETA3GNT1; iGAT; iGNT
Summary Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:25279699). Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1) (PubMed:23217742).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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