Mouse Gopc activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gopc
Locus ID	94221
Kit Components	GA211433G1, Gopc gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211433G2, Gopc gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211433G3, Gopc gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001199272, NM_053187
Synonyms	2210402P09Rik; AI844555; CAL; FIG; GOPC1; PIST
Summary	Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.[UniProtKB/Swiss-Prot Function]

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