Mouse Siglece activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Siglece
Locus ID	83382
Kit Components	GA211208G1, Siglece gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA211208G2, Siglece gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA211208G3, Siglece gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_031181
Synonyms	Cd170; mSiglec-E; Siglec5; Siglec9; Siglec12; Siglecl1
Summary	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.[UniProtKB/Swiss-Prot Function]

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