Mouse Skap1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Skap1
Locus ID	78473
Kit Components	GA210972G1, Skap1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA210972G2, Skap1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA210972G3, Skap1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001033186, NM_001177898, NM_001177899
Synonyms	1700091G21Rik; Scap1; Skap-55
Summary	Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity).[UniProtKB/Swiss-Prot Function]

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