Mouse Nfx1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nfx1
Locus ID	74164
Kit Components	GA209755G1, Nfx1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209755G2, Nfx1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209755G3, Nfx1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001290448, NM_001290449, NM_023739
Synonyms	1300017N15Rik; 3000003M19Rik; NFX.1; TEG-42; Tex42
Summary	Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.[UniProtKB/Swiss-Prot Function]

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