Mouse Marchf1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Marchf1
Locus ID	72925
Kit Components	GA209365G1, Marchf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209365G2, Marchf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209365G3, Marchf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001166372, NM_001166375, NM_001293784, NM_175188, NM_001363123, NM_001363124, NM_001363125
Synonyms	2900024D24Rik; BB085186
Summary	E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.[UniProtKB/Swiss-Prot Function]

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