Mouse Plekhf1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Plekhf1
Locus ID	72287
Kit Components	GA209184G1, Plekhf1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA209184G2, Plekhf1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA209184G3, Plekhf1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_024413
Synonyms	1810013P09Rik; APPD; LAPF; PHAFIN1; ZFYVE15
Summary	May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity).[UniProtKB/Swiss-Prot Function]

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