Mouse Prxl2a activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Prxl2a
Locus ID	70564
Kit Components	GA208559G1, Prxl2a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA208559G2, Prxl2a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA208559G3, Prxl2a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001316732, NM_001316733, NM_001316734, NM_001316735, NM_001316736, NM_001316737, NM_001316739, NM_001316740, NM_027464
Synonyms	5730469M10Rik; Adrx; AU040822; Pamm
Summary	Involved in redox regulation of the cell (By similarity). Acts as an antioxidant (By similarity). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (By similarity). May affect bone resorption and help to maintain bone mass (By similarity). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880).[UniProtKB/Swiss-Prot Function]

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