Mouse Dnajb11 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dnajb11
Locus ID	67838
Kit Components	GA207536G1, Dnajb11 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA207536G2, Dnajb11 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA207536G3, Dnajb11 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001190804, NM_001190805, NM_026400
Synonyms	1810031F23Rik; ABBP-2; AL024055; Dj9; ERdj3; ERj3p
Summary	As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.[UniProtKB/Swiss-Prot Function]

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