Mouse Frmd8 activation kit by CRISPRa

CAT#: GA207341

Frmd8 CRISPRa kit - CRISPR gene activation of mouse FERM domain containing 8



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

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经常一起买 (1)
FRMD8 Antibody - middle region
    • 100 ul

CNY 5,250.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol Frmd8
Locus ID 67457
Kit Components

GA207341G1, Frmd8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA207341G2, Frmd8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA207341G3, Frmd8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_026169
Synonyms 1200004M23Rik; 2310035N23Rik; 4931429L16Rik; AU018809
Summary Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway (PubMed:29897333). By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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