Mouse Twsg1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Twsg1
Locus ID	65960
Kit Components	GA206527G1, Twsg1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206527G2, Twsg1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206527G3, Twsg1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_023053
Synonyms	1810013J15Rik; 9030422N06Rik; AW552143; D17Ertd403e; Tsg; Twg
Summary	May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.[UniProtKB/Swiss-Prot Function]

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