Mouse Arpp19 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Arpp19
Locus ID	59046
Kit Components	GA206355G1, Arpp19 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206355G2, Arpp19 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206355G3, Arpp19 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001142655, NM_021548, NM_001357878, NM_001357879, NM_001357880, NM_001357881, NR_152135
Synonyms	19kDa; 2700024H10Rik; ARPP-19; Arpp12; AW559096
Summary	Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity).[UniProtKB/Swiss-Prot Function]

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