Mouse Necab3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Necab3
Locus ID	56846
Kit Components	GA206109G1, Necab3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA206109G2, Necab3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA206109G3, Necab3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_021546
Synonyms	2900010M17Rik; AI853434; Apba2bp; Nip1; XB51
Summary	Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta (By similarity). May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3 (By similarity).[UniProtKB/Swiss-Prot Function]

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