Mouse Pdlim5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Pdlim5
Locus ID	56376
Kit Components	GA205933G1, Pdlim5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205933G2, Pdlim5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205933G3, Pdlim5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001190852, NM_001190853, NM_001190854, NM_001190855, NM_001190856, NM_001190857, NM_019808, NM_019809, NM_022554
Synonyms	1110001A05Rik; AI987914; C87059; Enh; Enh1; Enh2; Enh3; LIM
Summary	May play an important role in the heart development by scaffolding PKC to the Z-disk region. Isoform 2 and isoform 3 may negatively modulate the scaffolding activity of isoform 1. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).[UniProtKB/Swiss-Prot Function]

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