Mouse Gkap1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Gkap1
Locus ID	56278
Kit Components	GA205885G1, Gkap1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205885G2, Gkap1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205885G3, Gkap1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_019832
Synonyms	42kDa; 4933400B15Rik; D13Ertd340e; Gkap42
Summary	Regulates insulin-dependent IRS1 tyrosine phosphorylation in adipocytes by modulating the availability of IRS1 to IR tyrosine kinase. Its association with IRS1 is required for insulin-induced translocation of SLC2A4 to the cell membrane. Involved in TNF-induced impairment of insulin-dependent IRS1 tyrosine phosphorylation.[UniProtKB/Swiss-Prot Function]

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