Mouse Sfmbt1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Sfmbt1
Locus ID	54650
Kit Components	GA205753G1, Sfmbt1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205753G2, Sfmbt1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205753G3, Sfmbt1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001166531, NM_001166532, NM_019460
Synonyms	4930442N21Rik; 9330180L21Rik; AA536974; Sfmbt; Smr
Summary	Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis.[UniProtKB/Swiss-Prot Function]

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