Mouse Tspan14 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tspan14
Locus ID	52588
Kit Components	GA205490G1, Tspan14 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205490G2, Tspan14 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205490G3, Tspan14 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001316748, NM_145928
Synonyms	AA958793; D14Ertd226e; Tm4sf14; tspan-14
Summary	Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126). Negatively regulates ADAM10-mediated cleavage of GP6 (PubMed:26668317). Promotes ADAM10-mediated cleavage of CDH5 (PubMed:23035126).[UniProtKB/Swiss-Prot Function]

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