Mouse Nckap1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nckap1
Locus ID	50884
Kit Components	GA205389G1, Nckap1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205389G2, Nckap1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205389G3, Nckap1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001290745, NM_016965, NM_001355410, NM_001355411
Synonyms	C79304; H19; Hem-2; Hem2; mh19; mKIAA0587; Nap1; p125Nap1
Summary	Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705).[UniProtKB/Swiss-Prot Function]

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