Mouse Ppp2r5c activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ppp2r5c
Locus ID	26931
Kit Components	GA205045G1, Ppp2r5c gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA205045G2, Ppp2r5c gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA205045G3, Ppp2r5c gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001081457, NM_001081458, NM_001135001, NM_012023, NM_001364204, NM_001364205, NM_001364206, NM_001364207, NM_001364208, NM_001364209, NM_001364210, NM_001364211, NM_001364212, NM_001364213, NM_001364214
Synonyms	2610043M05Rik; 2700063L20Rik; AI060890; AW545884; C85228; D12Bwg0916e; mKIAA0044
Summary	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity).[UniProtKB/Swiss-Prot Function]

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