Mouse Def8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Def8
Locus ID	23854
Kit Components	GA204782G1, Def8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204782G2, Def8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204782G3, Def8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001253783, NM_001253784, NM_001281803, NM_054046, NR_045593
Synonyms	AI449518; D8Ertd713e; DEF-8
Summary	Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970). Involved in bone resorption (PubMed:27777970).[UniProtKB/Swiss-Prot Function]

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