Mouse Tnfrsf10b activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tnfrsf10b
Locus ID	21933
Kit Components	GA204389G1, Tnfrsf10b gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204389G2, Tnfrsf10b gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204389G3, Tnfrsf10b gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_020275
Synonyms	DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A; TRICK2B; TRICKB
Summary	Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.[UniProtKB/Swiss-Prot Function]

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