Mouse Tle3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tle3
Locus ID	21887
Kit Components	GA204366G1, Tle3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204366G2, Tle3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204366G3, Tle3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001083927, NM_001083928, NM_009389
Synonyms	2610103N05Rik; ESG; Grg3a; Grg3b; mKIAA1547
Summary	Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). May play an important role during spermatogenesis.[UniProtKB/Swiss-Prot Function]

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