Mouse Tcf7l2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Tcf7l2
Locus ID	21416
Kit Components	GA204242G1, Tcf7l2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204242G2, Tcf7l2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204242G3, Tcf7l2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001142918, NM_001142919, NM_001142920, NM_001142921, NM_001142922, NM_001142923, NM_001142924, NM_001331135, NM_001331136, NM_001331137, NM_001331138, NM_001331139, NM_001331140, NM_001331141, NM_001331142, NM_001331143, NM_001331144, NM_001331145, NM_001331146, NM_001331147, NM_001331148, NM_001331149, NM_001331150, NM_009333, NR_138565
Synonyms	Tcf-4; Tcf4; TCF4B; TCF4E
Summary	Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.[UniProtKB/Swiss-Prot Function]

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