Mouse Serpina3g activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Serpina3g
Locus ID	20715
Kit Components	GA204061G1, Serpina3g gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA204061G2, Serpina3g gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA204061G3, Serpina3g gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_009251, NM_001353612, NM_001353613
Synonyms	2A2; AI119734; spi2; Spi2-1; Spi2/eb.1; Spi2A
Summary	Serine and cysteine protease inhibitor. Can inhibit lysosomal papain-like proteases including the cathepsins B, G, H, K, L and V. Ineffective against elastase, granzyme A, granzyme B, or caspases 3, 8 or 9. Inhibition of cytoplasmic cathepsin B following release from the lysosome may protect cells from apoptosis. This may facilitate the survival of progenitor T-cells and the subsequent development of long term memory CD8 T-cells.[UniProtKB/Swiss-Prot Function]

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