Mouse Nectin2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Nectin2
Locus ID	19294
Kit Components	GA203510G1, Nectin2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203510G2, Nectin2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203510G3, Nectin2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001159724, NM_008990
Synonyms	AI325026; AI987993; Cd112; MPH; nectin-2; Pvr; Pvrl2; Pvs
Summary	Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.[UniProtKB/Swiss-Prot Function]

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