Mouse Ptprr activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ptprr
Locus ID	19279
Kit Components	GA203499G1, Ptprr gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203499G2, Ptprr gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203499G3, Ptprr gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001161837, NM_001161838, NM_001161839, NM_001161840, NM_011217, NM_001358484
Synonyms	Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR
Summary	Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton.[UniProtKB/Swiss-Prot Function]

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