Mouse Ptpn12 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ptpn12
Locus ID	19248
Kit Components	GA203474G1, Ptpn12 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203474G2, Ptpn12 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203474G3, Ptpn12 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_011203, NM_001356591, NM_001356590, NM_001356592
Synonyms	P19-PTP; PTP-P19; PTP-PEST; PTPG1
Summary	Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:17070019). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (By similarity).[UniProtKB/Swiss-Prot Function]

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