Mouse Ptch1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ptch1
Locus ID	19206
Kit Components	GA203442G1, Ptch1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203442G2, Ptch1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203442G3, Ptch1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001328514, NM_008957
Synonyms	A230106A15Rik; mes; Ptc; Ptc1; Ptch
Summary	Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.[UniProtKB/Swiss-Prot Function]

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