Mouse Mdm4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Mdm4
Locus ID	17248
Kit Components	GA202622G1, Mdm4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202622G2, Mdm4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202622G3, Mdm4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001302801, NM_001302802, NM_001302803, NM_001302804, NM_008575, NR_126506
Synonyms	4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; Mdmx
Summary	This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

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