Mouse Dst activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Dst
Locus ID	13518
Kit Components	GA201141G1, Dst gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA201141G2, Dst gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA201141G3, Dst gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001276764, NM_010081, NM_133833, NM_134448
Synonyms	2310001O04Rik; A830042E19Rik; ah; athetoid; AW554249; BP230; Bpag; Bpag1; BPAG1-n; dt; Macf2
Summary	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1.[UniProtKB/Swiss-Prot Function]

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