Mouse Birc6 activation kit by CRISPRa
CAT#: GA200442
Birc6 CRISPRa kit - CRISPR gene activation of mouse baculoviral IAP repeat-containing 6
CNY 12,255.00
货期*
4周
规格
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Birc6 |
Locus ID | 12211 |
Kit Components | GA200442G1, Birc6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200442G2, Birc6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200442G3, Birc6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_007566 |
Synonyms | A430032G04Rik; A430040A19Rik; AA501170; Bruce; D630005A10Rik; mKIAA1289 |
Summary | Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development.[UniProtKB/Swiss-Prot Function] |
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基因表达相关资源 |
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