Human Coiled coil domain containing protein 111 (PRIMPOL) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PRIMPOL
Locus ID	201973
Kit Components	GA116411G1, Coiled coil domain containing protein 111 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116411G2, Coiled coil domain containing protein 111 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116411G3, Coiled coil domain containing protein 111 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001300767, NM_001300768, NM_001345891, NM_001345892, NM_001345893, NM_001345894, NM_001345895, NM_001345896, NM_001345897, NM_001345898, NM_001345899, NM_001345900, NM_001345901, NM_152683, NR_144312, NR_144313, NR_144314
Synonyms	CCDC111; MYP22; Primpol1
Summary	This gene encodes a DNA primase-polymerase that belongs to a superfamily of archaeao-eukaryotic primases. Members of this family have primase activity, catalyzing the synthesis of short RNA primers that serve as starting points for DNA synthesis, as well as DNA polymerase activity. The encoded protein facilitates DNA damage tolerance by mediating uninterrupted fork progression after UV irradiation and reinitiating DNA synthesis. An allelic variant in this gene is associated with myopia 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

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