Human U2AF1L3 (U2AF1L4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	U2AF1L4
Locus ID	199746
Kit Components	GA116316G1, U2AF1L3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116316G2, U2AF1L3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116316G3, U2AF1L3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001040425, NM_144987, NR_110171, NR_110172, NR_110173, NR_163171, NR_163172, NR_163173, NM_001369824, NR_163169, NR_163170
Synonyms	U2AF1-RS3; U2AF1L3; U2AF1L3V1; U2AF1RS3; U2af26
Summary	RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity).[UniProtKB/Swiss-Prot Function]

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