Human Nogo B receptor (NUS1) activation kit by CRISPRa

CAT#: GA114569

NUS1 CRISPRa kit - CRISPR gene activation of human NUS1 dehydrodolichyl diphosphate synthase subunit



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
NUS1 mouse monoclonal antibody, clone OTI6C11 (formerly 6C11)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


NUS1 (Myc-DDK-tagged)-Human nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) (NUS1)
    • 10 ug

CNY 2,400.00
CNY 3,990.00


NUS1 mouse monoclonal antibody, clone OTI6C11 (formerly 6C11)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol NUS1
Locus ID 116150
Kit Components

GA114569G1, Nogo B receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA114569G2, Nogo B receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA114569G3, Nogo B receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_138459
Synonyms C6orf68; CDG1AA; MGC:7199; NgBR; TANGO14
Summary This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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