Human TRMT1 (TRMU) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TRMU
Locus ID	55687
Kit Components	GA110883G1, TRMT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110883G2, TRMT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110883G3, TRMT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001008568, NM_001008569, NM_001008570, NM_001008571, NM_001282782, NM_001282783, NM_001282784, NM_001282785, NM_018006, NR_104240, NR_104241
Synonyms	MGC99627; MTO2; MTU1; TRMT; TRMT1
Summary	This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

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