Human PARL activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PARL
Locus ID	55486
Kit Components	GA110758G1, PARL gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110758G2, PARL gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110758G3, PARL gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001037639, NM_001037640, NM_001324436, NM_001324437, NM_001324438, NM_018622, NR_136893
Synonyms	PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1
Summary	This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]

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