Human RNF220 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RNF220
Locus ID	55182
Kit Components	GA110583G1, RNF220 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110583G2, RNF220 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110583G3, RNF220 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001319956, NM_001319957, NM_016501, NM_018150
Synonyms	C1orf164
Summary	E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).[UniProtKB/Swiss-Prot Function]

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