Human EXOSC4 activation kit by CRISPRa

CAT#: GA110149

EXOSC4 CRISPRa kit - CRISPR gene activation of human exosome component 4



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (2)
EXOSC4 rabbit polyclonal antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00


EXOSC4 (Myc-DDK-tagged)-Human exosome component 4 (EXOSC4)
    • 10 ug

CNY 2,400.00
CNY 3,705.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol EXOSC4
Locus ID 54512
Kit Components

GA110149G1, EXOSC4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA110149G2, EXOSC4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA110149G3, EXOSC4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_019037
Synonyms hRrp41p; p12A; RRP41; RRP41A; Rrp41p; SKI6; Ski6p
Summary Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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