Human SMOX activation kit by CRISPRa
CAT#: GA110139
SMOX CRISPRa kit - CRISPR gene activation of human spermine oxidase
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | SMOX |
Locus ID | 54498 |
Kit Components | GA110139G1, SMOX gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110139G2, SMOX gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110139G3, SMOX gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001270691, NM_019025, NM_175839, NM_175840, NM_175841, NM_175842 |
Synonyms | C20orf16; PAO; PAO-1; PAO1; PAOH; PAOH1; SMO |
Summary | Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN400156 | SMOX - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |