Human SETD4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SETD4
Locus ID	54093
Kit Components	GA110058G1, SETD4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110058G2, SETD4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110058G3, SETD4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001007258, NM_001007259, NM_001007260, NM_001007261, NM_001007262, NM_001286752, NM_017438, NR_040086, NR_040087, NR_040088
Synonyms	C21orf18; C21orf18, C21orf27; C21orf27; OTTHUMP00000108890; OTTHUMP00000108895; SET domain containing 4
Summary	Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response (PubMed:31308046). Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of proinflammatory cytokines IL6 and TNF-alpha (By similarity). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity).[UniProtKB/Swiss-Prot Function]

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