Human MRPL48 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MRPL48
Locus ID	51642
Kit Components	GA109916G1, MRPL48 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109916G2, MRPL48 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109916G3, MRPL48 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001030046, NM_001318498, NM_001318499, NM_001318500, NM_016055, NR_134658, NR_134659, NR_134660, NR_134661
Synonyms	39S ribosomal protein L48, mitochondrial; CGI-118; CGI-118, MGC13323; FLJ17047; FLJ99260; HSPC290; L48MT; MGC13323; mitochondrial ribosomal protein L48; MRP-L48
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

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