Human Phospholipase C epsilon 1 (PLCE1) activation kit by CRISPRa

CAT#: GA109642

PLCE1 CRISPRa kit - CRISPR gene activation of human phospholipase C epsilon 1



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
PLCE1 rabbit polyclonal antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00


PLCE1 (Myc-DDK-tagged)-Human phospholipase C, epsilon 1 (PLCE1), transcript variant 1
    • 10 ug

CNY 22,792.00


PLCE1 rabbit polyclonal antibody
    • 25 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol PLCE1
Locus ID 51196
Kit Components

GA109642G1, Phospholipase C epsilon 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109642G2, Phospholipase C epsilon 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109642G3, Phospholipase C epsilon 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001165979, NM_001288989, NM_016341
Synonyms NPHS3; PLCE; PPLC
Summary This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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