Human Siglec 7 (SIGLEC7) activation kit by CRISPRa

CAT#: GA108978

SIGLEC7 CRISPRa kit - CRISPR gene activation of human sialic acid binding Ig like lectin 7



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
SIGLEC7 mouse monoclonal antibody, clone OTI1A1 (formerly 1A1)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


SIGLEC7 (Myc-DDK-tagged)-Human sialic acid binding Ig-like lectin 7 (SIGLEC7), transcript variant 2
    • 10 ug

CNY 3,656.00
CNY 4,370.00


SIGLEC7 mouse monoclonal antibody, clone OTI1G7 (formerly 1G7)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol SIGLEC7
Locus ID 27036
Kit Components

GA108978G1, Siglec 7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108978G2, Siglec 7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108978G3, Siglec 7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001277201, NM_014385, NM_016543, NR_102350
Synonyms AIRM1; CD328; CDw328; D-siglec; p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2
Summary Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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