Human ZBTB20 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZBTB20
Locus ID	26137
Kit Components	GA108769G1, ZBTB20 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108769G2, ZBTB20 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108769G3, ZBTB20 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001164342, NM_001164343, NM_001164344, NM_001164345, NM_001164346, NM_001164347, NM_015642, NR_121662, NM_001348800, NM_001348801, NM_001348802, NM_001348803, NM_001348804, NM_001348805
Synonyms	DPZF; HOF; ODA-8S; PRIMS; ZNF288
Summary	This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]

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