Human Pirh2 (RCHY1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RCHY1
Locus ID	25898
Kit Components	GA108615G1, Pirh2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108615G2, Pirh2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108615G3, Pirh2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001008925, NM_001009922, NM_001278536, NM_001278537, NM_001278538, NM_001278539, NM_015436, NR_037913, NR_037914, NR_103723, NR_103724, NR_103725
Synonyms	ARNIP; CHIMP; hARNIP; PIRH2; PIRH2E; PIRH2F; PRO1996; RNF199; ZNF363
Summary	The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

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